ST. LOUIS - Missouri health officials have issued a warning about a dangerous new opioid impacting communities across the country. According to the Missouri Department of Public Safety, health officials have raised concerns about cychlorphine, a new synthetic opioid that is considered up to 10 times more potent than fentanyl. Health officials said ...

ST. PETERSBURG, Fla. (AP) The small-ball Milwaukee Brewers playing in the smallest market in the majors are World Series champions for the first time. Hey, Milwaukee: grab a brat, raise a beer and prepare for that parade. To borrow a line from Bob Uecker, your title drought is up, outta here, gone. Young ace [...]

ST. LOUIS (AP) Kristoffer Velde scored a goal in each half and added an assist to lead Portland to a 3-2 victory over St. Louis City on Wednesday night, keeping the Timbers' postseason hopes alive. Portland (11-14-7) pulled within two points of the final playoff spot in the Western Conference with two matches remaining. [...]

ST. LOUIS - The St. Louis region is gearing up for Halloween this weekend with a variety of events starting Thursday to celebrate the spooky season. The Halloween events begin Thursday night as The Wheel at Union Station allows visitors to bring their furry friends on the wheel from 10 a.m. to 9 p.m. Whether [...]

ST. FRANCOIS COUNTY, Mo. - A woman was killed after being struck by a vehicle on Highway 32 Wednesday night in Farmington. According to the Missouri State Highway Patrol (MSHP), the crash occurred around 7 p.m. on Missouri Route 32 east of Michigan Street. It involved a Chevrolet Spark. The crash happened as the woman [...]

ST. LOUIS - Unseasonably warm temperatures continue, but rain chances are beginning to return to the St. Louis region. A cold front is dropping southward Thursday morning. It will push into but not through the St. Louis area. So we stay warm, but the region could see more cloud cover and just a slight chance [...]

A tense meeting at the St. Louis County Council brought tenants, county department heads and attorneys representing the owners of Northern Village Apartments face-to-face.

St. Louis Mayor Cara Spencer is calling on the St. Louis Board of Police Commissioners to refocus their attention after publicly outlining her concerns Wednesday.

''Sometimes bad decisions are more fun and good decisions are boring," he allegedly told police.

A St. Louis man was sentenced Wednesday for his role in an attempted robbery of Bitcoin and a kidnapping in Danbury, Connecticut, in August 2024.

If you were to make a list of St. Louis landmarks, the one-of-a-kind Compton Hill Water Tower would likely be in the top five.

Prosecutors said the children were in the case of relatives or other trusted adults, who asked for money for food and milk in exchange for providing the defendant with pre-produced child sexual abuse material and livestreaming the abuse to other paying customers worldwide.

Missouri Secretary of State Denny Hoskins is projecting a higher statewide voter turnout than the 2022 Midterm Election.

Some St. Louis County residents tell FOX 2 they're seeing property tax figures online that don't reflect their senior property tax freeze, prompting questions and concerns.

Criminal charges have been dropped in a decades-old Southwest Missouri murder case.

KPLR 11 the CW will air several Saint Louis University Billikens men's basketball games in November and December, including next week's home opener.

Redevelopment efforts in Old North St. Louis are experiencing delays as local residents report that squatters occupying vacant properties are slowing neighborhood improvement plans.

A Metro East soldier missing since the Korean War is finally home. After 75 years, U.S. Army Private First-Class John Robert Stovall returned to Illinois this week after his remains were identified, allowing family, veterans and community members to honor his service and sacrifice.

A St. Louis County woman appeared in court Wednesday afternoon for child sex crimes.

Halloween is just a few days away, and many St. Louis-area residents are making the most of it with spooky scenes, festive decorations and frightfully-fun displays outside their homes.

A man who admitted to stabbing his co-worker at Walmart in Collinsville last year has been sentenced to decades behind bars.

Creve Coeur Lake will be closed to boats and other watercraft for five months, starting next week, as crews work to remove invasive carp.

Tower Grove Park is getting a major boost to help preserve one of its most recognizable landmarks. The park has been awarded a $750,000 federal Save Americas Treasures grant to restore the 154-year-old Music Stand Pavilion. It serves as a centerpiece for concerts, festivals and community gatherings.

A discovery decades in the making is helping connect Lutheran South's past with its future. Plus, Hazelwood KinderCare teacher Kimberly West, one of just 25 educators nationwide selected for KinderCare's 2026 Teacher of the Year Award.

A woman died Monday after a domestic dispute involving a vehicle in Franklin County, authorities say.