From the health benefits to side effects, here's what to know about the popular new GLP-1 weight loss medications.

On Friday around 8:30 p.m., deputies from the Ramona sheriff's substation stopped a gray 2004 Ford Ranger pickup with an expired registration and a damaged windshield near the intersection of State Route 78 at Poplar Street.

Pope Francis challenged the notion of walls that divide a common humanity. New art and activism in San Diego highlight this struggle.

A cycling infrastructure project between the San Ysidro international border crossing and the Bayshore Bikeway in Imperial Beach is nearing completion and should be open for use this summer.

A California woman's quest to say thank you led to the colonel who ran her refugee camp and the aircraft maintainer who helped with evacuations in 1975.

Another giant Navy oiler named for a civil rights icon -- the future USNS Sojourner Truth -- was launched at NASSCO in Barrio Logan.

Welcome to the National League West, which is far from a one-team show four weeks into the season, with the Padres - not L.A. setting the pace.

San Diego FCs losing streak continued Saturday when the expansion club fell 3-1 to Real Salt Lake at Snapdragon Stadium.

A 51-year-old man died early Saturday after his vehicle hit a concrete barrier off Pomerado Road in Poway, sheriff's officials said.

Steve Hilton and Chad Bianco lead the field of Republicans who hope to snap a long GOP losing streak in next years governors race.

Chula Vista police will hold a checkpoint Saturday in an attempt to catch those who are driving under the influence.

A fire broke out Saturday east of state Route 163 and firefighters had the flames surrounded, only to see them jump containment lines.

Superior Court Judge David Berry found probable cause for two felony charges against former agent Juan Prishker in a preliminary hearing.

Authorities asked for help Saturday in locating a woman who's been missing for nearly a week from an unincorporated area near Sycuan Casino.

If youre a big fan of dog movies that pull at your heart strings, you might enjoy Bill Murray in "The Friend."

A community crime spree escalated from vandalism to a home invasion early Saturday, leading to a man's arrest after a standoff at a Mira Mesa home.

An 82-year-old inmate died over the weekend after having been hospitalized for low blood pressure and a heart-related condition, San Diego County sheriff's officials said Saturday.

A 42-year-old motorist was killed Saturday in a two- vehicle collision in the East Village neighborhood and the other driver was arrested on suspicion of DUI, police said.

Homelessness and substance use disorder are closely linked, but many people struggling with both are unable to get the help they need.

Mission Fed ArtWalk returns to Little Italy this weekend for the 41st year featuring more than 250 local, national and international artists – including local moms. The event, which runs on both Saturday and Sunday, will feature Gretchen Weidner and Jen Duran. Learn more about them here.  Gretchen Weidner  San Diego resident Gretchen Weidner said […]

The San Diego Sheriff is investigating the death of a 12-girl who was struck after two vehicles collided in Encinitas.

A 54-year-old man is hospitalized Saturday after he suffered injuries sustained in a tractor/trailer collision in the Otay Mesa neighborhood of San Diego.

San Diego County residents who want to get rid of expired, unused or unwanted drugs will have the chance to safely discard them Saturday at multiple locations during National Drug Take Back Day.

A 51-year-old motorcyclist is hospitalized Saturday with multiple injuries after he was struck by a white Jeep whose driver fled after the collision in the Otay Mesa neighborhood of San Diego.

The Southern California Asian and Pacific Islander Festival will return to Oceanside's Civic Center Saturday, honoring 20 Asian, Native Hawaiian and Pacific Islander cultures.