WASHINGTON — A dozen prior leaders of the U.S. Food and Drug Administration — appointed by Republicans and Democrats alike — issued a scathing denunciation of new FDA assertions casting doubt on vaccine safety.

ACC commissioner Jim Phillips is pushing for No. 12 Miami to earn a bid to the College Football Playoff along with the winner of the league championship game between No. 16 Virginia and Duke.

Ten people were arrested in Washington County on Tuesday stemming from an incident on Aug. 17 in North Franklin Township.

Faced with a grim fiscal outlook and a dicey 2026 budget, City Council is taking a hard look at whether it can spare $10 million on affordable housing initiatives next year.

A solemn procession of law enforcement officers, first responders and public safety officials on Wednesday marked the final journey of Lucy, a beloved veteran bloodhound with the Greensburg Volunteer Fire Department Bloodhound Team.

T.J. Watt was a surprise addition to the Pittsburgh Steelers’ injury report Wednesday. The star outside linebacker sat out practice because of a toe injury, per the league-mandated status report.

The changing landscape of college football means the nation’s premier recruits are no longer signing with the same handful of programs.

Here’s a look at senior football players from the WPIAL who signed with Division I programs on the first day of the early-signing period Wednesday:

When he was asked Sunday night how he can get more in sync with his wide receivers, Pittsburgh Steelers quarterback Aaron Rodgers left the impression that attendance at weekly film study was not perfect.

Two high-ranking officials in Pittsburgh’s EMS bureau have been fired amid allegations of falsified overtime reports.

Penn State started Wednesday’s early national signing day with just four commitments in its 26 class, with a group that used to hold 25 dropping like flies. Many of them followed fired coach James Franklin to his new job at Virginia Tech.

As the story goes, when Tony Dorsett was a sophomore at Hopewell, coaches did not think he was big enough to play running back.

LOS ANGELES — A doctor who pleaded guilty to selling ketamine to Matthew Perry in the weeks before the “Friends” star’s overdose death is set to be the first of five people sentenced in the case on Wednesday.

PHILADELPHIA — Philadelphia Eagles offensive coordinator Kevin Patullo said a “line was crossed” when his New Jersey home was vandalized because the incident stretched beyond football and into his personal life.

Despite the cold weather outside, Wednesday was the hottest day on the calendar for college football recruits.

A virtual meeting is scheduled to discuss an upcoming project to replace a bridge carrying Anderson Road over Wible Run in Shaler.

WASHINGTON — The Pentagon’s watchdog found that Defense Secretary Pete Hegseth put U.S. personnel and their mission at risk when he used the Signal messaging app to convey sensitive information about a military strike against Yemen’s Houthi militants, two people familiar with the findings said Wednesday.

The North Hills School Board welcomed one new and three returning members when it reorganized on Tuesday, Dec. 2.

From Pat Narduzzi’s perspective, the early signing period probably is a roller coaster of emotions.

Two South Huntingdon residents were behind bars Wednesday after police said they took two children to a drug transaction in North Huntingdon, according to court papers.

A day after he was claimed off waivers, Adam Thielen was with the Pittsburgh Steelers running routes at practice Wednesday.

It’s not difficult to tell when Arturs Silovs hits the ice at practice.

Rural Appalachian communities in Pennsylvania know the feeling of being promised the world and left with the bill. For generations, coal powered the region’s economy. But when demand collapsed, so did entire towns. More than 33,000 mining jobs have vanished in Appalachia since 2011, leaving behind shuttered plants, hollowed-out tax bases and a painful ...

Since September of this year, the United States military has been blowing up boats allegedly trafficking drugs in the Caribbean.

The annual First Night parade will have a different look this New Year’s Eve.