A deadly motorcycle crash has closed eastbound single-motorcycle crash has closed eastbound Interstate 44 past Interstate 270 on Wednesday night, causing major traffic delays in the area.

A steady stream of hopeful residents filled the Edwardsville gun club, eager to uncover unclaimed, cash, and property. Icash is an Illinois state program connecting citizens with what they are owed.

A former Missouri Department of Transportation supervisor has been indicted on federal fraud charges and accused of using state-issued credit cards to make about $50,000 in personal purchases for watches, clothes, cologne, and accessories for his vehicles.

A new sculpture measuring 10 times the scale of a typical human head has been installed outside the St. Charles County Historical Society along historic Main Street.

Two of the hottest issues of the day brought a group of discontent Missourians to the state capitol rotunda, Wednesday, for a citizen-led hearing on artificial intelligence and data centers.

Twin sisters from Ethiopia who were born conjoined at the head have been successfully separated after a complex surgical procedure in St. Louis.

The recall, first initiated in June by the St. Louis-based Intercon Chemical Co., concerns six different varieties of soap sold under several brand names.

A man is behind bars on a felony charge after a bomb threat Tuesday that targeted an Archdiocese of St. Louis venue in Shrewsbury.

The Kansas City Chiefs expect to have cornerback Mansoor Delane on the field when they play the Indianapolis Colts on Sunday night, less than a week after the sixth overall pick in the draft hurt his shoulder on the opening series of his NFL debut against the Denver Broncos.

Aramark is preparing to lay off 69 employees after losing its contract to provide food services at St. Louis-area Boeing sites, according to a Missouri WARN Notice.

Drew Gilbert hit a two-run home run in the 10th inning, lifting the San Francisco Giants to a 6-5 victory over the St. Louis Cardinals on Wednesday afternoon.

The Bridgeton Police Department says it is reviewing an officer's use of force during an arrest after a video of the encounter circulated on social media.

Two people are in custody after an early morning shooting in Belleville that investigators say involved an exchange of gunfire between a juvenile inside a home and people in a passing vehicle.

An investigation is underway after police say a husband stabbed his wife to death Wednesday morning in Centralia, Illinois.

Investigators are urging the public to come forward with information in a Cahokia Heights homicide investigation, with CrimeStoppers offering a reward of up to $5,000 for tips that lead to a felony arrest.

OConnells Pub, a beloved Irish bar and restaurant in south St. Louis, is preparing to close doors within the next year.

A St. Louis County lawmaker is asking state regulators to take a closer look at Ameren Missouris proposed rate increase, arguing that residential customers should not be responsible for costs tied to growing electricity demand from data centers and other large users.

A man convicted of operating a $35 million Ponzi scheme that targeted Missouri investors, reportedly including Kansas City Chiefs tight end Travis Kelce, has been sentenced too 11 years in federal prison.

The City of St. Louis is now considered a safe and welcoming city for immigrants, according to a new designation from national immigrant organization Welcoming America.

Missouri Gov. Mike Kehoe has signed an executive order to establish strict safeguards over the use of Automated License Plate Reader technology in the state, including Flock cameras.

The recall, first initiated in June by the St. Louis-based Intercon Chemical Co., concerns six different varieties of soap sold under several brand names.

Over the next several weeks, hummingbirds will migrate south from Missouri in search of warmer climates for the fall and winter months. These tiny travelers will gradually leave the Show Me State, marking the end to their spring and summer stay.

Tens of thousands of Catholics will fill the Dome at Americas Center for the upcoming beatification Mass for Archbishop Fulton J. Sheen. The service will bring the archbishop one step closer to sainthood.

WASHINGTON (AP) A bill that proposes to fix some of the biggest problems in college sports spiraling spending, constant lawsuits and a transfer portal run amok cleared a major hurdle Tuesday when the Senate voted 74-24 to halt debate and move the measure one step closer to a final up-or-down vote. The [...]

FRANKLIN COUNTY, Mo. - A woman was injured after being struck by a train overnight Wednesday in Robertsville. According to the Missouri State Highway Patrol's Dallas Thompson, the incident occurred shortly after 1:15 a.m. under Highway O at Circle Drive and Yaeger Street. The woman was taken to a hospital after the crash, MSHP said. [...]